Sentence examples for modified base in from inspiring English sources

The positions of each modified base in the PaP1 genome indicated the presence of modified bases in this genome.

However, the sequence contexts in which hmC occurs in vivo are not known, and the role of this modified base in maintenance methylation is unclear.

Because 5hmC is most abundant in brain tissue, it has become a priority to understand the function of this modified base in the brain.

A high percentage of the 5′-G A TC-3′ motif sites were detected to be adenine methylated in both genomes (Table  2 and Additional file 1: Figure S2, 97.8% and 98.9% for RM13514 and RM13516, respectively; modified base in bold, underlined base indicates methylation on the complementary DNA strand), suggesting a functional role of DNA adenine methylase (Dam) in both strains.

We hypothesized that the MmeI modified base in the ITR was important for recognition by the Himar1 transposase in vivo, resulting in a transposase-DNA complex that often failed to engage the initially encountered ITR and instead read through to a downstream non, contiguous ITR within the concatemer [ 38].

Structural studies of the msiA modified base in bacterial tRNAPhe show the methylthiol group functions to stabilize codon anticodon interactions through cross-strand stacking with the base of the first nucleotide of the mRNA codon; such interactions improve translational fidelity by preventing frame shifting and misreading during translation.

The biosynthetic pathway to modified bases in genomes can occur at the level of modified mononucleotides subsequently incorporated via polymerase-mediated DNA synthesis or post-DNA synthesis from the canonical bases within DNA.

Raiber, E.-A., Hardisty, R., van Delft, P. & Balasubramanian, S. Mapping and elucidating the function of modified bases in DNA.

The current study has tested this hypothesis by focusing on modified bases in the A-site region of the large subunit.

In principle, this approach could enable sequencing of modified bases in long reads (>10 kbp).

In their early work, Gupta and Woese identified four positions with modified bases in H. volcanii 16S RNA[ 30].