Sentence examples for modified at multiple from inspiring English sources

On the basis of detailed mass spectrometric analyses, there are at least 15 different types of covalent histone modifications, and since histone proteins are modified at multiple sites, and different stoichiometries, the total number of histone marks is >160.

An electro-positive groove formed by tandem ARM repeats serves as a binding site for the JMD and CBD, which can be postranslationally modified at multiple sites; depending on the site, the interaction between cadherin and catenins is either strengthened or weakened (Dupre-Crochet et al., 2007).

Our analysis indicates that about 17%% of the predicted sites of methylation in rRNA are modified in more than one species and that the average number of species modifying at these multiple hit sites is just less than three.

hTRPV4-ARD was modified at endogenous cysteines by a 5 kDa PEG-maleimide, resulting in multiple shifted bands on SDS PAGE.

In clinical trials on multiple sclerosis, adverse hypersensitivity reactions were seen with classic APLs modified at key TCR contact sites [ 30, 31].

The multiple sequences alignment suggested that the five genes in Table 1 whose expression was modified at P < 0.01 were not identical.

Multiple mechanisms have been postulated for this effect, which seems to be indirect.. Furthermore, Bcl-2 is transcriptionally regulated but can also be post-translationally modified by phosphorylation at multiple sites, which can alter Bcl-2 activity or drive proteasome-mediated degradation.

For example, a variety of sporadic human cancers have been found to harbor hyperactive canonical WNT signaling, leading to the constitutive activation of β-CATENIN, a key polyvalent protein that is modified by phosphorylation at multiple sites.

Designing microstructure for damage tolerance requires a detailed understanding of how an advancing crack interacts with the microstructure (and sometimes modifies it locally) at multiple length scales.

With CRISPR, researchers have modified or disabled multiple genes at once, in some cases leaving no trace of the foreign DNA that makes it possible.

In addition to the complexity of multiple subtypes, H1 subtypes are post-translationally modified, primarily by phosphorylation at multiple sites.