The version of the pretest used in phase III is included in Supplemental Material B. J.C.H. designed the Evolutionary Evidence lesson plan; we modified aspects of this lesson plan based on observations made during the interview process.
As part of a thorough examination of fidelity of implementation, it is helpful to consider examples of how and why facilitators modify aspects of the target program to fit the needs of the participants and their unique context.
Therefore we also present simulation experiments exploring the effects of modifying aspects of the existing model to better simulate the montane situation (ecotone structure, changes in the wind rose to mimic the effects of topography on aerial pollen transport).
This engineered version of herpes simplex virus type 1 (HSV-1) is the product of decades of preclinical work aimed at identifying and modifying aspects of the viral genome involved in virulence and immunogenicity.
There is also strong evidence emerging that dietary manipulation in cats may be able to modify aspects of the aging process, with a long-term longitudinal study of cats demonstrating both survival and health benefits from feeding a diet supplemented with antioxidants, fatty acids, and a prebiotic source.
These findings suggest that modifying aspects of the stress response system via early environmental manipulation may lead to improved cognitive functioning during aging.
Likewise, modifying aspects of the analysis of anatomical lesions did not substantially change the main findings.
Modifying aspects of the nursing work environment may reduce or prevent these complications in hospitalised dementia patients (and, indeed, in other patients).
The definition given here of "a clinical study design that uses accumulating data to decide on how to modify aspects of the study as it continues, without undermining the validity and integrity of the trial," is often quoted as definitive.
There is no universally accepted definition of these designs, but a working definition might be "a multistage study design that uses accumulating data to decide how to modify aspects of the study without undermining the validity and integrity of the trial".
