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Therefore, the text was not modified as recommended by the referee.
Author's response: The text was modified as recommended and the legend to Figure 2 corrected.
The MetS was defined according to the U.S. 2004 National Cholesterol Education Program (NCEP) Adult Treatment Panel III guidelines [ 27] and modified as recommended in the latest American Heart Association/National Heart ,Lung, and Blood Institute Scientific Statement for fasting glucose and waist circumference [ 28].
The MetS and metabolic risks were defined according to the US National Cholesterol Education Program Adult Treatment Panel III guidelines [ 11] and modified as recommended in the latest American Heart Association/National Heart , Lung and Blood Institute Scientific Statement [ 12] by adopting a lower cut-off for fasting glucose (≥5.6 mmol/L).
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The Diamondbacks' self-perception has been modified as well.
Authors' response: modified as suggested.
The evaluated parameters allowed the assessment of the outcomes of numerous metabolic pathways that would tentatively result in a distinguishable phenotype in the modified plants, as recommended in the Guidance Document (Section III, D7) described by the EFSA GMO Panel [ 29].
As the instruments use different rating scales leading to marked differences in the magnitude of the scores (i.e., OPQoL-Brief scores can be up to 13 times larger than those for the ASCOT and EQ-5D-3 L), Z scores of utilities/summary scores were calculated for the modified plots as recommended in the literature [ 49– 51].
Left ventricular ejection fraction was assessed using the modified Simpson method as recommended by the American Society of Echocardiography.
Left ventricular ejection fraction (LVEF) was calculated using the modified Simpson rule as recommended by the American Society of Echocardiography (10).
The second most sensitive and specific method was the BAX® system, using the modified enrichment protocol as recommended by the manufacturer for faecal samples.
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