Sentence examples for modified antibody was from inspiring English sources

The modified antibody was then purified by gel filtration chromatography.

The modified antibody was purified from culture supernatants using Protein-A, cation-exchange chromatography and subsequent size-exclusion chromatography.

Comparing a modified therapeutic antibody (different Fc part) with its original antibody, the resulting half-life for the modified antibody was shorter.

Nineteen known viral epitopes were sortagged to a cell-specific antibody, and a cocktail of these modified antibodies was used to immunize a group of mice.

Work on using microbial transglutaminase to modify antibodies was first published by Schibli, whose group showed that Q295, the natural amino acid residue that is situated near the N297 glycosylation site, could be a substrate for transglutaminase, but only if the N-glycan was first removed.

After the SH-modified antibody was washed with PBS-EDTA buffer in a G-25 column, the maleimide-modified particles were added.

The antibody was first covalently coupled to norbornene, and this stock of norbornene-modified antibody was then reacted with tetrazines bearing the chelators 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid (DOTA) or desferrioxamine (DFO) and subsequently radiometalated with Cu and Zr, respectively.

This strategy does not necessarily offer a significant improvement in facility compared to popular DOTA-NHS or DFO-NCS antibody modification protocols; more importantly, however, it creates a modular platform in which a common, covalently modified antibody can be modified with a wide variety of chelators and radiometals.

It could be assumed that the modified antibody might less be able to bind to the FcRn and thus, was less protected from elimination (Fang et al, 2007).

A recent study showed that enzymatically modified antibodies can be used to generate highly targeted, potent immune responses.

Consequently, a modular system one in which the divergent point is a single covalently modified antibody stock that can be reacted selectively with various chelators would resolve these issues and allow for more versatility and cross-comparisons in the development of antibody-based radiopharmaceuticals.