Sentence examples for modified animal model from inspiring English sources

This article focuses on a unique genetically modified animal model that predicts the in vivo response of antiplatelet agents in humans more accurately than is currently possible using conventional murine models of thrombosis.

In a recently modified animal model cachexia is induced by inoculation of C26 tumour cells in mice.

In most experimentally modified animal model systems, single-gene mutations in many different genes have major life extension effects (Fontana et al., 2010; Kenyon, 2010).

In this genetically modified animal model we could demonstrate a marked deficiency in the number of new neurons generated in the hippocampi of p50−/− mice [ 86].

Here, we present what is to our knowledge the first analysis of the effect of PD-fluid exposure in a genetically modified animal model.

To confirm the requirement of ERα for the ameliorating effects of E2 treatment on arthritis by using a genetically modified animal model, total ERα-/ and their corresponding WT littermates (experiment 2, see Materials and methods) were challenged with antigen according to the regimen illustrated in Figure  1A.

Many genetically modified animal models are providing new keys for unlocking the pathophysiology of cartilage degradation.

The aim of the chapter is to help investigators to find out the best genetically modified animal models for their studies.

The discovery and development of new products, especially medical therapies, increasingly rely on genetically modified animal models to define new targets, elucidate mechanisms of disease, and screen products for efficacy and safety.

Nuclease-mediated genomic modification of somatic cells coupled with somatic cell nuclear transfer (SCNT) provide a new approach for creating genetically modified animal models and allow for the direct comparison of mutations in an otherwise isogenic setting.

Genetically modified animal models that are deficient in the four different SG subunits have also been developed, and their phenotype is associated with skeletal and cardiac myopathies [14] [18].