Sentence examples similar to modified and lacks from inspiring English sources

The PAMAM dendrimer used in the present study was surface-modified and lacks free primary amine groups required to form a complex with siRNA.

Fruit fly embryos that had been genetically modified to lack this and similar genes were covered in spine-like projections, so the scientists called the group of genes "hedgehog genes".

These females produce genetically identical daughters (barring spontaneous mutations) through a modified meiosis that lacks recombination and segregation of homologous chromosomes (Blackman 1987).

The complete infertility in genetically modified mice lacking kisspeptin [48] and its cognate receptor GPR54 [49], or lacking prokineticin 2 [50] or prokineticin receptor 2 [51] suggests that some peptidergic systems are of critical importance in hypothalamic control of fertility.

Human colorectal carcinoma cell line HCT116, their genetically modified derivates lacking TP53, HCT116TP53KO, and the osteosarcoma cell line HPS11 were grown in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 100 units/ml penicillin, 100  μg/ml G-streptomycin and 2 mmol/l ℒ-glutamine.

To establish TNFR specificity and discriminate receptor usage in the development of PF, BLM was administered to genetically modified mice lacking either receptor (tnfRI−/− and tnfRII−/− ).

To decipher the role of TNF and TNF-mediated inflammation in the development of fibrosis, we have utilized the bleomycin-induced animal model of Pulmonary Fibrosis and a series of genetically modified mice lacking components of TNF signaling.

Strikingly, treatment of oral SCC cells with 9,10-dihydro-15-Deoxy-Δ-PGJ2 (CaY10410), a structurally modified 15d-PGJ2 that lacks the α, β-unsaturated carbonyl, failed to inhibit Jak1 and Stat3 constitutive phosphorylation levels.

In this regard, genetically modified mice lacking D2 receptors exhibit behavioral working memory deficits and reduced activity of the prefrontal cortex during treatment with D1 agonists [10].

In addition, studies with mice expressing a dominant negative TRβ mutant spontaneously develop metastastic thyroid carcinoma [23] and pituitary tumors [24], and increased aggressiveness of skin tumors is found in genetically modified mice lacking TRs [22], further demonstrating the role of these receptors as inhibitors of tumor progression.

Using genetically modified mice lacking either GluK1 or GluK2, we have shown unambiguously that GluK2 and not GluK1 subunit contribute to the recorded KAR currents.