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Methods: Various TAFC modifications with various substitution (different carbon chain length acyl compounds as well as charge substitutents) were prepared and labelled with 68Ga.
Thereafter, these polymer chains are maturated by sulfated modifications with various sulfotransferases, which transfer the sulfate group from a sulfate donor, 3′-phosphoadenosine 5′-phosphosulfate, to the corresponding hydroxyl groups at each sugar residue of the backbone, and by epimerization of the GlcUA residue with C5-epimerases [ 3– 5, 8, 9, 35].
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Here, we report a further improvement of protein contrast agents ProCA1 for in vivo imaging by protein modification with various sizes of polyethylene glycol (PEG) chain.
The surface sol gel technique was used to deposit ultrathin metal oxide gel film to uniformly coat the cellulose nanofibers of bulk cellulose substances and for further modification with various functional building blocks to fabricate nanostructured materials.
The distinct hierarchical structures and morphologies of natural cellulosic substances (e.g. ordinary laboratory filter paper) provides ideal platforms for the surface modification with various guest species that are immobilized or deposited onto the surfaces of the exquisite structure details.
They often serve as precursors for modification with various tailoring enzymes that result diverse compounds with numerous bioactivities such as thaxtomin A and gliotoxin.
It has been reported that the dispersity of GoldMag can improved through surface modification with various macromolecular organic compounds, such as 11-mercaptoundecanoic acid (MUA) [7], polystyrenesulfonate (PSS) [8], and polyethylenimine (PEI) [9].
By modification with various biocompatible molecules, significantly improved stability and reduced toxicity have been achieved.
Gene modification with various factors such as Bcl-2 and PlGF significantly promoted the survival of ESCs and MSCs [ 13, 111].
Another novel approach for the application of BE in cancer therapy may be its chemical modification with various ligands which allows obtaining an enhanced cytotoxicity towards tumour cells, better solubility, and bioavailability than the parental compound [ 33].
The chemical nature of aptamers is based on the nucleic acid molecule, affording many distinct advantages in bioapplications, such as small size, nontoxicity, ease of synthesis and chemical modification with various functional groups, and facile surface immobilization.
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