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Further studies with other histone modifications will be necessary to elucidate the complete epigenetic regulation of these genes in pluripotent stem cells.
Further studies involving structural modifications will be necessary to decrease their toxicity to eukaryotic cells, maintaining or increasing the antibacterial activity.
Looking to the future, although the algorithm performance was not degraded for MS subjects, we expect that modifications will be necessary to handle other pathologies such as microcysts, drusen, and geographic atrophy (GA).
Moreover, experiments showing abolishment of imprinting from disruption of these histone tail modifications will be necessary to determine their role in imprinting, and to prove that their presence is not just a mere consequence of imprinted expression.
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Current design methods, for high temperatures in ENV1993-1-2 ambient ambientemperaturere in ENV1993-1-3, can provalida valid basis of calculation but modification will be necessary, depending on the exact model of stress strain relationship of cold-formed steel at elevated temperatures.
This modification will be necessary as we need to compare models not on the whole text but only at words with a given context.
Pan-genome dynamic studies of bacteria differing in recombination-related features such as competence, mismatch repair, and restriction modification systems will be necessary before a thorough picture of bacteria genome species concepts can be attained.
Additional studies investigating protein interacting partners and post-translational modifications of CHD2 will be necessary to understand how abnormal CHD2 leads to photosensitive epilepsy.
As a result, minor modifications to the ground will be necessary.
Thus, the off-target profile for 12 was determined to be relatively clean, and the significance of dopamine transporter inhibition, though noted, is measured given that modifications to the protoype scaffold will be necessary to advance the compound series.
This modification was included to allow future studies in which modification of a reporter mRNA will be necessary.
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