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Taken together, the quercetin conjugates with appropriate structural modifications were shown to have a potential to serve as a scaffold for the design of novel MDR-reversal agents.

In addition, some surface modifications were shown to improve the vector stability, membrane permeability, and/or endosomal escape.

Structural modifications were shown to be essential for promoting the biological activity of this EPS and providing a GAG mimetic compound [ 9– 12].

In PsCDH modified GC electrodes, both the COOH-PD/SWCNT and the NH2-PD/SWCNT modifications were shown to provide a favorable environment for enzyme deposition.

Although dietary modifications were shown to alter cholesterol secretion in the intestine, a high cholesterol diet failed to affect TICE [ 49].

Interestingly, tubulin post-translational modifications were shown to influence the recruitment of protein complexes such as MAPs (i.e. Tau, MAP1B) or plus-end tracking proteins (p150Glued, EB1, CLIP170) onto microtubules (Verhey and Gaertig, 2007).

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Optimal design modifications are shown to increase productivity by ∼25%.

The synthesized signal with pitch modifications is shown in Figure 11.

These modifications are shown to improve the solver speed, the results quality, and allow for a wider areas of application.

A summary of the dynamics for all of these modifications is shown (see Additional file 2).

Examples of naturally occurring DNA base modifications are shown in Figure 1.

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