Epigenetic modifications are related to many human diseases.
We first show that calendering induces modifications of the surface on all length scales measured and that these modifications are related by straightforward transformations.
The proposed modifications are related to: the weighting procedure of the principal stress axes; the definition of the equivalent normal stress by taking into account the mean normal stress effect; the expression of the quadratic combination of stresses.
Using a bottom-up strategy effectively destroys information on how those individual chemical modifications are related, meaning researchers may be able to see that given modifications are present, but are largely blind to their interplay and stoichiometry.
It has been reported that most histone modifications are related to the positioning of nucleosomes [ 14, 15].
In contrast to promoter-targeted histone modifications, we have shown recently that cellular levels of histone modifications are related to cancer prognosis (Seligson et al, 2005).
Because CX3CR1 is an important survival pathway, it is unclear whether these modifications are related to defects in chemotactic signal or cell survival.
Subsequently, other studies have identified more genes whose epigenetic modifications are related to alteration of both semen parameters and fertility maintenance.
It triggers gene activation within few hours in several tumor or stem cell lines (Jergil et al. 2009, 2011), and it is well recognized that epigenetic modifications are related to the developmental neurotoxicity of the drug.
