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Such modifications are frequent and include the formation of disulfide bridges, glycosylation and most commonly phosphorylation.
The analysis set included 600 patients, of which 363 showed early response with Definition 1 and 417 with Definition 2. Initial treatment modification was frequent, and highest in patients without early response (48.1% with Definition 1).
Consumer-enforced change is frequent — recent examples include the cancellation of Facebook Beacon and Google Buzz, and Apple's modifications to geolocation files stored on consumer devices.
However, dose modifications were more frequent during the first versus second 12 months on treatment in both the bosutinib (dose interruption, 59% vs. 27%; dose reduction, 38% vs. 10%) and imatinib (dose interruption, 40% vs. 18%; dose reduction, 17% vs. 5%) arms.
Violent strikes were frequent.
There were frequent blackouts.
Winter storms were frequent.
Among the potential modifications are more frequent testing and additions to the list of banned substances.
There are other challenges beyond behavior modification: Power cuts are frequent, so plants cannot be relied on to operate continuously.
Any patients meeting any exclusion criteria, those on vasoactive drugs, such as prostanoids, or patients undergoing frequent treatment modifications, were excluded.
Modifications were most often motivated by mycological results, and de-escalation was the most frequent change.
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