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These modifications were documented by scanning electron microscopy for bacteria treated with the inhibitor.
Delays and reductions were related to neutropenia, and the reasons for the dose modifications were documented.
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Previously registry data were grouped according to a modified version of the International Classification of Diseases for Oncology (ICDO-2; Kramárová et al, 1996) and modifications are documented by Cotterill et al (2000).
In this survey, aiming at analysing data on PLD use in breast cancer treatment in a "real life" setting, PLD doses and their modification were documented cycle by cycle.
Further details of the current MVS procedure of distance modification are documented in Methods S1.
The mmLDL modification appeared to be very reproducible, and a successful modification was documented in a biological assay in which mmLDL induced spreading of J774 macrophages in cell culture [ 13, 19].
In the DHCS only toxicities leading to a modification are documented and therefore the risk of adverse events might be substantially higher than the incidence reported in our study.
The use of glucocorticoids in the treatment of rheumatoid arthritis (RA) has evoked controversy for more than half a century. 1 2 3 4 5 Disease modification was documented during the 1950s, 6 but toxicities of long-term glucocorticoids in pharmacological doses of prednisone or prednisolone of 10 mg/day or more, as was the clinical practice in the 1950s, 7 were inevitable.
Modifications of antihypertensive therapy were documented and whether patients reached blood pressure targets was determined.
Details of diagnoses of diabetes (date of diagnosis, details of the criteria for diagnosis, hypoglycemic medication prescribed, and lifestyle modifications prescribed) during the study were documented on case report forms at the closing study visit as described previously based on reporting by investigators (11).
All modifications to the initial SPECT/CT report and differences to the (final) xSPECT/CT reports were documented.
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