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Building on its multiscale and mechanistically enhanced sensitivity to landscape modifications, we applied this calibrated tool to a theoretical landscape planning problem.
The model modifications we applied to obtain partial measurement invariance should be replicated, to ascertain the generalizability of our results as well.
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If needed, that is, if the age adjustment failed, we applied modifications to the boundaries of the youngest and the oldest age groups to enhance calculability: the boundaries of these age groups were modified so that the age-specific survival in these (youngest and oldest) age groups could be calculated.
If contradictory modifications were not detected, then we applied the modifications to iNJ661m and verified that 1) the wild-type growth rate (calculated from FBA) was greater than the minimal rate, 2) incorrect predictions were corrected, and 3) correct predictions (TP or TN) were still correct.
To describe the histone modification process, we apply a model recently developed by Binder et al. (2013).
26 This will result in approximately 280 cases, allowing for the inclusion of up to 28 variables in the regression model to adjust the estimations of the OR for potential sources of confounding and/or effect modification when we apply the 10 outcome cases per variable rule.
After a normalization procedure that corrects the read counts taking into account the control sample, the different sequencing depths of the datasets and the nucleosome abundance at each locus, we obtained a joint histone modification level distribution and we applied the k-means clustering algorithm on it (see Supplementary Material for more details).
"We applied certain modifications that in our opinion are quite interesting.
We applied some modifications [44] to the method described by Chishti et al. [21] and Janus et al. [45].
We applied two modifications to improve TNMCA.
Since we had no prior information to discriminate among these networks, we applied all modifications to iNJ661 m.
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CEO of Professional Science Editing for Scientists @ prosciediting.com