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To facilitate predictive compound design in a better way than it is currently possible via directed structural modifications, we also plan to incorporate biological activities and ADME/Tox properties into the morphing process.
In making modifications, we also considered harmonization with other reporting guidelines, such as Consolidated Standards of Reporting Trials (CONSORT) 2010.
To control for age-dependent transcript modifications, we also investigated changes occurring in age-matched wild-type (WT) mice.
Based on the probabilistic interpretation of fold-changes in enzyme levels resulting from gene modifications, we also estimate the resulting reaction flux capacities as probability distributions.
In addition to these two modifications we also replaced the column clean-up with an automatable bead-based approach which allows increased throughput.
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Based on the electrochemical modification, we also predict the carbonation depth of blended cements with different slag contents.
To control for possible confounding/effect modification, we also determined lead in blood (Lin et al. 2003).
To determine if there was statistically significant (p < 0.05) effect modification, we also ran models that included multiplicative interaction terms.
In addition to doing detailed adjustment for individual-level confounders and evaluating potential effect modification, we also adjusted for a community-level measure of SES to help account for confounding (Marmot 2001).
In addition, to analyse the impact of ApoB-BD modification we also compared the behavioural exploratory phenotype of MPS-IIIA mice treated with fully modified sulphamidase with that of MPS-IIIA mice treated with partially modified sulphamidase.
To investigate whether there was a relationship between sample size and evidence for effect modification, we also conducted the LRT for effect modification between APOE genotype and smoking status in each study individually, and plotted the P-values derived from LRT against sample size, grouped by whether the original publication reported evidence of effect modification.
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