Only the modified elements since the last validation and those affected by such modifications are validated, according to what described in Sect.
Potential modifications were validated by manual inspection of the MS/MS data.
Modifications were validated by cross-checking with village population lists provided by Savera, a local nongovernmental organization.
The modification was validated against experimental studies and the comparison showed better agreement than the basic constant heat transfer (CHTC) model in FLOW-3D.
Sites of modification were validated by manual interrogation of tandem mass spectra using Xcalibur 2.1 Qual Browser software (Thermo Scientific).
Substrates were dried for 24 h at RT. Surface modification was validated by quantifying changes in contact angle using the sessile drop method on a goniometer (First Ten Angstroms FTA1000, V2.1), and by X-ray photoelectron spectroscopy of key samples (see Supplementary Methods).
Participants were assigned to antitubercular therapy if clinicians identified a focal process compatible with tuberculosis either on physical examination or radiographic imaging using modifications of previously validated case definitions [9].
This modification has been validated on a Spanish population with adequate psychometric properties [ 19].
The plus-maze was a modification of that validated for mice by Lister [ 22] and comprised two open (30x5x25 cm) and two enclosed (30x5x25 cm) arms which extended from a common central platform (5x5 cm).
Later minor modifications have never been validated [ 5- 7].
The set of the 32 items kept and the 13 items deleted was discussed by a pluridisciplinary group (nephrologists, interviewers, and methodologists), who accepted and validated the modifications.
