Sentence examples for modifications to target from inspiring English sources

Figure 4 shows further modifications to target Hg II) and Pb II).

16, 54 Since as many as 90% 95% of patients with T2DM are also overweight or obese, it is imperative to implement lifestyle modifications to target not only the glycemic control in these patients, but also the hypertension, hyperlipidemia, and other CV risk factors often associated with obesity.

The 5C2H ligand showed a very high selectivity towards PDE10A, greater than 5000 fold, which emphasizes the consideration of compound 8 for analog modification to target the selectivity pocket in order to improve the folds of selectivity towards PDE10A.

Although fullerenes have previously been identified as possible ion channel blockers [10 15], no studies have demonstrated the potential of designing fullerenes through chemical modification to target specific ion channels.

Thus, the detailed strategy to focus a library for ALK + MET + EGFR polypharmacological inhibition is first to identify compound classes that provide ALK + MET co-inhibition, and then to select scaffolds from these that in addition allow modification to target covalent inhibition of EGFR.

In addition, hydrogen bonding with Tyr683 in the PDE10A selectivity pocket is also seen in many other highly selective PDE10A inhibitors reported in the literature [44] (PDB ID: 5DH5, [45] 5B4L, [46] with Ki = 0.23 nM, and IC50 = 0.76 nM respectively), which further highlights the importance of analog modification to target the PDE10A selectivity pocket.

66 Exosomes after modification to target breast cancer cells could be used to deliver doxorubicin (dox).

Realized applications range from genome editing to epigenome modification to targeted gene regulation to chromatin labeling and capture.

Next Generation Sequencing of female tissues has uncovered novel small RNAs missed by prior analyses and allows the identification of sequence differences reflective of potential post-transcriptional modification relevant to target regulation [20].

The present paper deals with the study and development of an oral dosage form devised to release drugs following a programmed time period after administration or, when opportune design modifications are introduced, to target the colon.

Modifications were made to target the relatively young Ves3ML SINE subfamily, which is specific to vesper bats (Ray et al. 2015).