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It reopened in 2002 after modifications to stabilize it.
We hypothesized that by the use of personalized models, we can suggest treatment modifications to stabilize PSA levels.
To allow peptides to access the intracellular targets, two approaches have been developed recently: (1) conjugation to the cell-penetrating peptides such as HIV-tat, oligoarginine, and Pep-1 and (2) chemical modifications to stabilize the secondary structures and optimize the physicochemical properties.
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Delivery of the oligonucleotides, choice of vector, chemical modification to stabilize against nucleases and avoidance of side effects (e.g. stimulation of interferons) are major challenges.
Our work contributes to the understanding of the factors necessary for the successful expression and purification of P2X receptors, highlights the need for construct modification to stabilize trimers (in the case of hP2X4) and demonstrates that DdP2XA is both an interesting and ideal candidate with which to pursue higher-resolution structural studies.
Rather, the modification to stabilized peak and mean stresses resulting from either thermal relaxation of peened stresses or a time dependent shake down of stress under mechanical loading governs ultimate behaviour.
Unlike for cytosolic expression, nuclear T7 transcripts containing a viral translation enhancer element did not express GFP, and modifications designed to stabilize and facilitate export of T7 transcripts to the cytosol did not improve the expression.
To gain insight into the nature of the fusogenic conformational changes in gB, we used several approaches aimed at engineering the prefusion form of the herpes simplex virus type 1 gB ectodomain, including modifications intended to stabilize the prefusion form and novel mutations aimed at destabilizing the postfusion form.
This suggests that once adipogenic commitment is initiated, patterns of chromatin modifications tend to stabilize.
Chemical modification intended to stabilize HBOCs in the tetrameric or polymeric forms introduces conformational constraints that result in proteins with diverse allosteric responses as well as oxidative and nitrosative redox side reactions.
Small design modifications are introduced to stabilize the system.
More suggestions(15)
modifications to account
modifications to generate
modifications to modulate
modifications to make
modifications to establish
modifications to include
modifications to determine
modifications to induce
modifications to be
modifications to reflect
modifications to meet
modifications to create
modifications to identify
modifications to work
modifications to detect
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