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During embryonic development, the crabp1 promoter is demethylated to induce gene expression in specific tissues [ 56], while in adult tissues, the promoter becomes inaccessible through chromatin modification to restrict its expression [ 57].
Replication competent adenoviruses with various E1 modifications designed to restrict their replication to tumor cells are being evaluated as oncolytic agents in clinical trials.
An additional strength in the study size is the ability to assess effect modification and to restrict analyses to never smokers and never HT users.
Moreover, targeted expression strategies can be used to restrict modification to a small subset of cells in living animals.
The number of virus passages in eggs was limited to one in order to restrict genome modifications linked to laboratory manipulation.
We intended to restrict the modification to only one nucleotide and keep the rest with native DNA structure.
| Regulators to restrict payday lending.
"A campaign to restrict contraband?
Try to restrict drinking to special occasions.
During adaptation to restricted fetal development, modifications to nuclear receptors act to optimize growth and differentiation.
But because AID expressed in bacteria did not show a difference, the modifications need to be restricted to those also found in bacteria.
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