Sentence examples for modifications to lead from inspiring English sources

In contrast to classical global QSAR models that attempt to predict the absolute numbers of ADME (absorption, distribution, metabolism, excretion) and toxicological properties, MMP analyses predict the difference in (bio-) chemical properties that can be expected due to small chemical modifications to lead structures, with a much smaller and well-controlled error than global QSAR models.

The rule is likely to lead to modifications in the way options are structured.

These modifications could lead to enhancements and an automated sampling analysis system coupled to MS, using aqueous media.

These modifications may lead to a too late HO problem.

DNA methylation and histone modifications can lead to gene silencing, for example.

Under the same assumptions there exist higher rank modifications which lead to simple systems.

Both modifications together lead to a very sharp edge at the object boundary, see the red curve in Figure 4.

These modifications may lead to a destabilization of some proteins under the extraction conditions.

As olfactory and vomeronasal neurons are constantly renewed by peripheral neurogenesis following apoptosis, we asked whether the presynaptic modifications may lead to neurogenesis modifications.

However, such modifications could lead to the amplification of non-orthologous closely related loci.

We examined whether these modifications would lead to revelation of any training effects.