Sentence examples for modifications to histones from inspiring English sources

The 'histone code' is a well-established hypothesis describing the idea that specific patterns of post-translational modifications to histones act like a molecular 'code' recognized and used by non-histone proteins to regulate specific chromatin functions.

ENCODE contains information about methylation and chemical modifications to histones and the binding activity of transcription factors (TFs) and the DNA elements that regulate genes.

Epigenetics studies have revealed that chemical modifications to histones can be inherited and define how the information in genes is expressed and used by cells.

As histone modifications and cytosine methylation play a role in the activity of genes, aberration in the pattern of modifications to histones and DNA, called epigenome, can lead to disease.

Reversible covalent post-transcriptional modifications to histones are considered to form one of the major means by which gene transcription and DNA replication are controlled [ 1].

We and others have previously shown that epigenetic modifications to histones may serve as a molecular memory of the in utero exposure, rendering the risk of adult disease.

These results correlate high levels of non-S phase intergenic transcription with domain-wide active histone modifications to histone H3.

Besides DNA methylation, additional factors are known to regulate imprinted gene expression, including the covalent modifications to histone proteins associated with DNA [12] [16], the CTCF protein, [17] [22], and physical interactions between the two parental chromosomes [23] [28].

These marks affect chromatin structure, and include cytosine methylation of DNA and modifications to histone proteins.

Histone modifications are catalysed by a large variety of histone-modifying enzymes, which are able to read, add or remove covalent modifications to histone proteins [ 42].

We first investigated modifications to histone H2A and H2A.X-F upon maturation of oocytes to eggs through GVBD.