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The results could suggest further structural modifications to discover more potent and selective HMG-CoA reductase inhibitors.
The core pentapeptide analog X can be used as the lead compound for further chemical modifications to discover potential insecticides.
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Diab says she went through three different loan modifications only to discover that the bank had foreclosed more than a year before.
Many borrowers complain they were told by mortgage companies their credit would not be damaged by accepting a loan modification, only to discover otherwise.
An alternative, and orthogonal, approach is to integrate individual histone modification maps to discover latent relationships between epigenetic marks.
Mr. Galicia, who is now studying at Harvard University, was an intern at the Digital and the Wireless Communications Departments at Bell Laboratories in New Jersey during the past two summers and has created a computer model that was used to discover innovative modifications in the Orthogonal Frequency Division Multiplexing system.
Herein, we describe the modification of the spacer moiety to discover an alternative scaffold.
The intent was to discover a modification with a pattern that was a mirror to that of H3K27me3, known to be centrally important in the Polycomb-induced silencing mechanism [ 2].
Certain chemical similarities between these modifications make this scenario intuitively satisfying, as there is no a priori reason for convergent evolution to discover such similar modification substrates.
Scientists have used the shotgun pro−teomics approach to discover many protein modifications of interest.
Therefore, we sought to discover patterns of histone modifications that contribute to epigenomic reprogramming during EMT, and how changes in these modifications relate to the signaling events that are known to establish the mesenchymal phenotype.
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