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As this neural network cannot account for post-translational modifications, the sequence analyzed was the primary structure of the protein.
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Although the parent peptide did not form a hydrogel, small modifications to the sequence (one side chain or an N-terminus modification) led to hydrogels with properties (eg. gelation time and rheology) that could be tuned by these small alterations.
Minor modifications on the sequence of questions and format were made on the basis of the pilot study.
Fine-tuned functions should therefore mainly result from the many possible posttranslational modifications and the sequence differences between duplicates.
In the first step, the exact position of the modifications in the sequence was established by an adopted version of the phosphoRS algorithm [ 40].
These changes are transmitted from the gene to the protein in the guise of modifications of the sequence or the abundance of mRNA.
As a result, the modification in the sequence of DcR3 to produce FLINT (LY498919) should result in a pharmacologically superior molecule in the therapeutic intervention of diseases in which the pathogenesis is linked to FasL-mediated apoptotic or inflammatory events.
The C terminal and N terminal modification with the sequence G-DOPA-G shows similar adsorption rate and mass adsorption coverage at saturation; however it is presented a more loosely layers on the G-DOPA-G-TeT-124.
A new strategy of micro-structural design for improving combination of electrical conductivity and strength in Al alloy is developed based on modification of the sequence of conventional cold-deformation and artificial aging.
Also it has been shown that many of these diseases result from protein aggregation due to a genetic mutation and posttranslational modification in the sequence of the disease-related protein.
The motif table contains the minimotif amino acid sequence and any post-translational modification to the sequence.
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