Although the homopolymeric tract-containing Cj1295 gene is responsible for this modification, the question of why this occurs remains unanswered.
However, many issues remain to be resolved, such as the residues affected by acetylation, the enzymes involved and the mechanism that induces the modification, the question of why the response seems to be limited to UV, and whether this function of MTH2 is at all related to its role in preventing mutagenesis by hydrolysis of 8oxo-dGTP.
The sheer number of novel modifications begs the question how many more types of PTMs are there remaining to be found?
If simultaneous firing of hippocampal neurons during explorative-learning behaviour is sufficient for temporary synaptic modification, then the question arises as to whether similar cooperative firing can trigger persistent alterations in synaptic strength.
Slight modifications to the questions used to select likely voters in order to account for "the increasing prevalence of early voting".
Questions were sourced, with some modifications, from the questions asked in the end of course assessment following a continuing dental education course organized by the Academy of Dental Therapeutics and Stomatology, United States of America, in 2007 [ 7].
Western blot analysis of histones from mouse, Drosophila, Caenorhabditis Elegans, and Saccharomyces cerevisiae indicate that this modification is conserved, raising the question as to what role this modification may play in these organisms [ 30].
Unlike genetic mutations, epigenetic modifications are reversible, raising the question of whether aging and longevity can be changed if we are able to change the age-associated epigenome.
Modifications were made to the question on 'problems encountered in transfer of care process' based on feedback received during the pilot testing, i.e. to rank response options according to order of frequency, from most common [ 1] to least common [ 8] encountered problem.
After modifications, the draft key questions are posted to the DERP Web site for public comment.
