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In conventional experiments to determine post-translational modifications the interpretation of the mass spectra can be difficult because of neutral losses and the small concentration of the modified protein.
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We list here some limitations of our study that could in principle allow for modifications in the interpretation of our results.
19– 22 Different strategies to improve the sensitivity of genotypic methods to detect X4 variants have been examined, including simple modifications in the interpretation algorithms, 23 or adding structural/biochemical properties of the V3 loop and clinical parameters such as CD4 and CD8 counts, and plasma viremia in the final report interpretation.
Dual-color FISH was performed as previously published with slight modification of the interpretation criteria [ 12].
Adaptive responses to a genetic modification may also confound the interpretation.
The interpretation of modifications of the P1m N1m P2m complex by the gap is problematic because waves elicited by different stimulus features may overlap and cause an apparent change in peak amplitudes.
This indicates that a considerable number of differences between the COX + or COX++ lines and the Col-3 also occur naturally and are hence not specific to the genetic modification (for interpretation of the specific changes, see the ORA results section).
They were then introduced to the interpretation bias modification paradigm, which in the case of the written presentation group involved the participants working through the cards in self-paced fashion.
While this approach is useful, it also has limitations since in the extreme case, where no histones are present in a region, the denominator in the normalization would be zero, leading to the interpretation that modification level would be infinitely high.
In the case of human remains, the interpretation of these modifications has been controversial [21] [27].
The interpretation of this modification is highly context-dependent, as phosphorylation of the particular residue at different stages of the cell cycle results in completely different and often opposite biological effects.
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