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This strategy involves multiple and hierarchical chromatin modifications that regulate nuclear dynamics in response to a developmentally programmed signal(s), presumably of paracrine origin, before the resumption of meiosis.
As Myc activity directly correlates with protein expression, further complexity is provided by post-translational modifications that regulate Myc in normal stem cells or deregulate it in malignant stem cells.
We can not exclude the possibility that there are additional amino acids that have phospho- or some other post-translational modifications that regulate Sso protein function.
Finally, the physical interactions of GEF proteins with specific membrane receptors may allow the GEFs to be in a unique subcellular localization for post-translational modifications that regulate activity.
H3.3 is found decorated with various histone modifications that regulate transcription and maintain chromatin integrity.
Epigenetics refers to heritable modifications that regulate gene expression without changes to DNA sequence [ 6].
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Altered expression of several transcription factors and genes involved in chromatin modification that regulate these processes were also observed.
The structurally flexible N-terminal regulatory domain includes sites for posttranslational modification that regulate the stability and function of β-catenin.
Methylation at arginine residues (R) is an important post-translational modification that regulates a myriad of essential cellular processes in eukaryotes, such as transcriptional regulation, RNA processing, signal transduction and DNA repair.
Next, Ma et al. profiled DNA methylation, an epigenetic modification that regulates gene-expression patterns9.
DNA methylation represents a fundamental epigenetic modification that regulates chromatin architecture and gene transcription.
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