Sentence examples for modifications that plays from inspiring English sources
Reversible lysine acetylation is one of the most important protein posttranslational modifications that plays essential roles in both prokaryotes and eukaryotes.
DNA methylation is one of the main epigenetic mechanisms, alongside histone modifications, that plays a significant role in gene silencing [ 1], tissue differentiation [ 2], cellular development [ 3], X-chromosome inactivation [ 4], or genetic imprinting [ 5].
Early histone acetylation is strongly associated with regions that we have previously shown to be bound in early embryos by the maternally deposited transcription factor Zelda, suggesting that Zelda triggers a cascade of events, including the accumulation of specific histone modifications, that plays a role in the subsequent activation of these sequences.
Covalent histone modifications, notably methylation, are reversible posttranslational modifications that play key roles in chromatin structure, gene transcription and the epigenetic state of the cell (Martin and Zhang, 2005; Mosammaparast and Shi, 2010).
The IP is subject to a host of post-translational modifications that play a central role in regulating its function.
Moreover, chromatin modifications that play pivotal roles in the regulation of gene expression were reported to modulate 15-LOX expression.
This is in contrast to tail modifications that play a mainly indirect role in chromatin regulation through recruitment of effector proteins.
MS tools are increasingly being utilized to characterize the numerous post-translational protein modifications that play a role in the tumor microenvironment - for example, through their impact on the cross-linking of matrix proteins [ 21].
Polyubiquitination is an essential posttranslational modification that plays critical roles in cellular signaling.
Phosphorylation is a post-translational modification that plays a significant role in diverse biological phenomena.
The remethylation cycle is essential for the systemic methyl donor supply, which is used for important biological processes, such as cytosine-5 methylation of genomic DNA, an epigenetic modification that plays an important role in maintaining genomic stability, chromatin structure, and in controlling transcriptional capacity [2], [9].
