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Chemical modifications that increase the hybridization affinity of oligonucleotides are reasoned to confer higher potency, i.e., modified oligonucleotides can be dosed at lower concentrations to achieve the same effect.
In conclusion, modifications that increase the uptake of α-crystallin proteins into cells, without destroying their chaperone-like activity and anti-apoptotic functions, create the potential to use these proteins therapeutically.
The DoD estimates that there will be 8 million smartphones in service over the next three years, and most devices used to handle classified data have been subjected to pricey modifications that increase their final cost up to four times.
Baulcombe stresses that the next generation of GM crops will benefit from scientists having access to the deciphered genomes of plants, which should allow modifications that increase yields or allow current yields to be maintained with less damage to the environment.
This region is necessary for expression of the gene and is affected by epigenetic modifications that increase the chromatin accessibility specifically in endothelial cells.
In response to DNA damage, p53 undergoes a number of posttranslational modifications that increase its stability and transcriptional activity.
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All were based on the US Diabetes Prevention Programme protocol or the Finnish Diabetes Prevention Study, with modifications that increased feasibility and access.
Therefore, the protection afforded by HMW tropomyosins may be a result of increased expression and posttranslational modification that increases their association with the hypoxic actin cytoskeleton.
The IC-modification that increases the SDO, QO, and IFCCO or decreases the SDFe can make the catalyst more powerful.
Here, we present evidence that the autoprocessing reaction proceeds via an internal thioester intermediate and results in a covalent modification that increases the hydrophobic character of the signaling domain and influences its spatial and subcellular distribution.
An affect that increases the body's ability to maintain its distinctive ratio is paralleled in the mind by a modification that increases that mind's power of thought, and the passage from lesser to greater power is joy (IIIp11s, Affect Def. II).
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CEO of Professional Science Editing for Scientists @ prosciediting.com