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This information is stored in the model during each simulation as a set of conditions, which must be satisfied (i.e. possible combinations of histone modifications that exist in nature).
A major advantage of top-down MS is that combinatorial patterns of modifications that exist on a single histone molecule can be identified [38], which is particularly valuable in outlining the global landscape of PTMs on histone proteins.
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Chait pointed out that if a sufficient number of fragments are observed, top-down MS can provide a complete description of the primary structure and reveal all mass-altering modifications, as well as any correlations that exist between these modifications.
Modes are properties that exist only as modifications of the essential (principal) and the general attributes of a substance.
Down by the River In the 1930s, a group of Scandinavians from San Francisco built the string of summer cottages that exist today, with some modifications, along the banks of San Francisquito Creek.
Body modification was a scene that existed, but it was still very early days.
This constitutes the core of Spinoza's pantheism: God is everywhere, and everything that exists is a modification of God.
Methylation of cytosine in nuclear DNA is a common form of epigenetic modifications that has been reported to exist in mammals and plants.
The two-month investigation by the safety agency concluded that "no discernible defect trend exists" and modifications that G.M. already has agreed to make are sufficient to reduce the potential for a fire.
James, who is a professor of microbiology and molecular genetics, also said this is the first model of a malaria vector with a genetic modification that might be able to exist in wild populations and be passed down through generations, without the mosquitoes' fitness being compromised.
Initially, it was believed that histone methylation may be irreversible, despite early biochemical work suggesting that enzymatic activities that remove these modifications may exist in cells [ 4, 5].
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