Sentence examples for modifications that determine from inspiring English sources
On the other hand, measuring expression of the inflammatory mediator genes may not reflect the functional activity of the end-protein, because this also depends on translation and various posttranslational modifications that determine whether the protein becomes active.
To this purpose, proteomics studies are a powerful tool to better understand where to set the boundary line of healthy aging and age-related disease by analyzing the variation of protein expression levels and the major post translational modifications that determine "protein" physio/pathological fate.
They also demonstrate how opposing hormonal and intracellular signals can be integrated via histone modifications that determine chromatin structure and transcriptional activity of the promoter.
Alternatively, establishment of good biomarkers for detection of weak checkpoint signaling, such as antibodies to post-translational modifications that determine strong vs weak signaling, may facilitate this.
Surface and cytoplasmic nucleolin are differentiated from nuclear nucleolin by a slight shift in their isoelectric point, probably as a consequence of specific co- and/or post-translational modifications that determine routing of the newly synthesized nucleolin to the nucleus or the plasma membrane [6].
When HMGB1 emerges from the cell during apoptosis, necrosis, or pyroptosis, it can have redox and other post-translational modifications that determine its activity.
In some cases, such as at H3K27 and H3K9, acetylation or methylation can occur at the same histone residue and it is the balance between these opposing modifications that determines the transcriptional status of that region (Rice and Allis, 2001; Tie et al, 2009; Jung et al, 2010; Pasini et al, 2010b).
It is known that L is an essential modification that determines both the codon and amino-acid specificities of tRNAIle (Muramatsu et al, 1988; Soma et al, 2003).
It is well accepted that the accessibility of chromatin to transcription factors is dependent on post-translational modification of histones that determine the conformational state of chromatin.
Interestingly, this domain has been proposed to function as a 'molecular switch' (Greiner and Yang, 2011) controlled by multiple post-translational modifications that can determine the fate of mhtt exon-1 either by rendering it innocuous or enhancing its pathogenicity.
Their stability is affected by methylation because it protects the piRNAs, and other small ncRNAs, from other kinds of modifications, such as uridylation, that determine the speed of RNA degradation.
