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No number of modifications seems to be changing that.
The link between DNA methylation and histone modifications seems to be mediated by Methyl CpG DNA binding proteins, a member of which MeCP2 plays an important role to establish this interaction [14].
Although the mechanisms for maintenance of DNA methylation patterns are relatively well understood, the abundance of histone modifications seems to fluctuate with progression through the cell cycle (Bonenfant et al, 2007).
The extent of these modifications seems to be exceptional in the Odonata compared to other non-holometabolous Pterygota, which mostly exhibit a complete set of muscles from the first instar onward e.g. [ 11, 12].
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So far, the modifications seem to be working.
The intracellular redox status and the closely associated membrane modifications seemed to be related to membrane instability, loss of surface area through vesiculation, echinocytosis and stomatocytosis.
However, the magnitude of the transcriptome modifications seemed to be earlier, faster, and bigger in septic shock, as regards of the extent and rapidity by which the deregulation occurred.
Age-associated modifications seem to be regulated in a cell type specific manner.
In addition to direct control of gene transcription, post-transcriptional modifications seem to be very important for T cell development, homeostasis and activation as well.
These two post-translational modifications seem to be linked since, in at least some cases, tyrosine phosphorylation is monoubiquitination-dependent [11].
These modifications seem to be related to modifications in contractile and metabolic proteins, previously elucidated by proteomics and molecular analyses.
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