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The inclusion of such design modifications results in a significant reduction of the TBR for different breeder blanket concepts.
Introduction of LNA monomers around the functionalised 2′-amino-DNA modifications results in reversal of the affinity-decreasing effect of the latter.
The balance of active and repressive histone modifications results in the establishment of a "histone code", which together with DNA methylation, determines the specific lineage choice and defines the differentiation stage of a cell.
Lack of one or both lipid modifications results in diminished signalling activity of the protein.
Importantly, the combination of different modifications results in specific transcriptional or structural outcomes, underlining the existence of a "histone code" [ 9, 10].
Furthermore, loss of estrogen receptor (ER) expression due to aberrant DNA methylation and histone modifications results in resistance to anti-estrogen therapy in breast cancer.
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Such modifications result in chlorinated polyethylene (CM) or chlorosulfonated polyethylene (CSM), a virtually noncrystalline and elastic material.
All modifications resulted in qualitatively the same results.
The modifications result in the loss of some fish guilds.
However, these modifications resulted in greatly decreased solubility.
When combined, these genetic modifications resulted in a fourfold increase in intracellular sucrose accumulation.
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