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We represent the histone modifications profiles for these three groups in Figure 2b and Additional file 4: Figure S4.
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Consensus histone modification profiles for subsets of "ON/OFF" genes were visualized based on expression levels as described above.
In generating the first genome-wide histone modification profiles for a marsupial, we identified the first gene that is imprinted in a marsupial but not in eutherian mammals.
Recently we reported initial results on the tRNA modification profiles for L. lactis, which were obtained using multiple RNases and a standard DDA-based LC-MS/MS strategy.
5) I would have liked to see some analyses of chromatin states in these cells, specifically histone modification profiles for H3K27me3 and H3K4me3 (or H3K27ac).
Applying the above steps to the array data and subsequently averaging replicate intensities), histone modification profiles for the four hematopoietic cell types were derived and subsequently investigated for their association with lineage commitment [ 28].
In order to investigate this issue, we have characterised histone modification profiles for H3K4me3 and H3K27me3 in two more differentiated cell types, NPCs and MEFs, at the TSS of all imprinted genes using source data from Mikkelsen et al. [ 50].
Histone modification profiles for HMEC cultures were also very informative for the four intragenic or far-upstream regions that displayed breast cancer-associated DNA hypermethylation as well as a positive association between DNA methylation and expression among TCGA breast cancers (Additional file 1: Table S2).
These allow the visual study of the differential expression between two specific samples or sets of samples, the identification of the most highly expressed miRNAs within sample pairs (or sets of samples) and also the projection of the modification profile for specific miRNAs across all samples.
We examined histone modification profiles of human sperms.
We also examined the pyrosequenced regions in ENCODE histone modification profiles, which were available for HMEC but not for MCF-7 (ENCODE/Histone Modifications by ChIP-seq/Broad Institute).
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