Sentence examples for modifications play pivotal from inspiring English sources

Histone modifications play pivotal roles in chromatin remodeling and gene regulation.

Histone expression and histone post-translational modifications play pivotal roles in chromatin remodeling and epigenetic regulation in plant development [ 38- 40].

It is becoming widely accepted that perturbations of epigenetic modifications play a pivotal role in the onset, progression and maintenance of cancer.

Epigenetic modifications play a pivotal role in modulating gene expression during development and tissue differentiation, in the establishment and maintenance of genomic imprinting, and in X chromosome inactivation in female mammals.

Moreover, chromatin modifications that play pivotal roles in the regulation of gene expression were reported to modulate 15-LOX expression.

Besides disuse and bone denervation, other systemic factors, such as hormonal modifications, may also play pivotal roles in the development of osteoporosis after SCI.

Previous studies have indicated that each neuronal phenotype possesses a specific differentiation program, in which in addition to transcription factors [ 7], epigenetic modifications and non-coding RNA expression play pivotal roles.

Many of these modifications, such as phosphorylation, are known to play pivotal roles in the regulation of protein function.

Various epi-miRNAs, including miR-29, miR-152, and miR-290, have been shown to play pivotal roles in regulating the epigenetic modifications that occur through DNA methylation (Ji et al., 2013).

Methylation and de-methylation of histone lysine residues play pivotal roles in mammalian early development; these modifications influence chromatin architecture and regulate gene transcription.

Covalent modifications of the N-terminal tails of the core histones play pivotal roles in chromatin remodeling and in gene regulation (Millar and Grunstein 2006).