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These modifications play fundamental roles in gene regulation and other chromatin-based processes.
Several histone modifications play fundamental roles in the maintenance of embryonic stem cells, particularly with respect to their developmental potential (Bloushtain-Qimron et al., 2009; Jiang et al., 2011); histone modifications are also associated with the maintenance of stem cells in adult tissues (Buszczak et al., 2009).
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Epigenetic marks, such as DNA methylation and histone modifications, play a fundamental role in the neuronal plasticity required for learning and memory.
These modifications play a fundamental role in transcriptional regulation but also other processes such as replication.
Database URL: http://proteininformationresource.org/pirwww/iprolink/eFIP.shtml Post-translational modifications play a fundamental role in regulating the activity, location and function of a wide range of proteins.
Epigenetic modifications play a central role in differentiation and development.
It is currently proposed that histone modifications play vital roles in many fundamental biological processes by rearranging the structure and composition of chromatin.
In eukaryotic cells, small non-coding RNAs have been demonstrated to play fundamental roles in gene expression modification during development (Zamore & Haley, [2005]).
Microbes play fundamental roles in maintaining biosphere health.
Many ribosomal proteins play fundamental roles in ribosome assembly [ 5].
KATP channels play fundamental roles in cellular physiology.
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