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The relatively low frequency of genetic modifications outside the futA and futB loci supported our hypothesis of homologous recombination events taking place at a high frequency between the two paralogous α1,3-FucTs.
There are also multiple reported post-translational parkin modifications outside of the Ubl domain, including S-nitrosylation [ 128, 129] and NEDDylation [ 130], which have been reviewed recently [ 123].
These animals did display altered CORT responses to an acute episode of restraint stress following the chronic stressor, suggesting that epigenetic modifications outside of the central nervous system may have functional relevance.
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Dose modification outside the standard dose requirements while occurring infrequently 50-700% of the pediatric caregivers modified dosages in only '1-20'1-20%atients') reflects individual patient factors.
The current protocols include cell isolation from the patient followed by their genetic modification outside the body and subsequent re-introduction into the patient as an autologous transplant (ex vivo gene therapy).
Therefore, while there are certainly limitations that need to be considered when a reactive metabolite is added exogenously to a cell rather than generated intracellularly, for certain reactive metabolites the profiles of modification outside and inside a cell may be similar.
The cement can make a mess, so it's preferable to perform this modification outside or over top of a piece of paper.
The threat of a principal reduction in bankruptcy would have served as a stick to have modifications done outside court, experts said.
What's more, over two-thirds of modifications occur outside of the program.
Molecular mechanisms involved in Gli1 and Gli2 function have so far addressed specific residues affected by post-translational modifications occurring outside the DNA binding domain.
Although a small portion of the IF signal could be detected in the nuclei (data not shown), the vast majority of this histone modification localized outside the nuclei (Figure 1).
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