Introduction: Pharmacopoeial or manufacturer's radiochemical purity (RCP) analysis methods are not always practical in a hospital setting, leading to modifications or substitution with quicker, simplified, or cost effective analytical procedures.
The assignment may provide that such modification or substitution is a breach by the assignor.
RNA editing is one post-transcriptional process that involves insertion, deletion, modification or substitution of single nucleotide or a stretch of nucleotides on RNA.
This is consistent with previous SAR studies showing that modification or substitution of the 2-pyrimidyl group has less influence on these affinities compared with those of the other moieties of bosentan22.
Examples could include consumer education, research, materials modification or substitution, development of new products or services, exposure reduction, public policy efforts, fieldwork, third-party auditing, adoption of new codes, insurance, employee training or other actions.
The framework of five criteria could be adapted by modification or substitution of indicators or adaptation of thresholds among classes, and thus be applied to other species of conservation importance.
The development of such analogues has been achieved primarily through modification or substitution of the diammine carrier ligands of the parent compound.
If statistically significant and metrically relevant DIF is identified, then a modification or a substitution of this item should be performed, with subsequent testing of equivalence with the original.
This may be achieved, e.g., by structural modifications or deformations introduced by cation substitution or doping or creating of solid solutions of BiFeO3 with other materials with ABO3 type of structure.
Modifications and substitutions are often made for reasons of economy and convenience.
