Sentence examples for modifications or marks from inspiring English sources
Whether Myc dynamically regulates other histone modifications (or marks) at its binding sites also remains to be addressed.
Equally important, the distinct chromatin modifications or marks can act as beacons to recruit specifically recognition domains and components(readers) of transcriptional complexes, which thus serve as the effectors of the modification.
Conventionally, this includes CpG methylation, histone modification or marking, and gene imprinting, but recent evidence shows that small RNAs could also play a critical role in directing epigenetic silencing.
To uncover this large collection of new genes, the Broad scientific team looked not at the RNA molecules themselves but at telltale signs in the DNA called chromatin modifications or epigenomic marks.
Histones are highly basic globular proteins, with N-Terminal "tails" which can be heavily modified by a variety of posttranslational modifications, or histone marks [3].
Enzymes adding and removing these modifications or 'marks' are generally referred to as writers and erasers of the histone code respectively, and protein modules binding and interpreting the marks, as readers of the code [ 7].
The authors propose a model in which the DNA 6mA modification either restricts or marks the positions of nucleosomes near transcriptional start sites in Chlamydomonas.
miRNA stability is influenced by the 3′ end sequence motif or modification that mark miRNAs for degradation or protect them against exonucleolytic activity, depending on the specific miRNAs and the tissues.
The identification of binding sites by transcription factors, polymerase, or histone modification marks plays a crucial role for identifying the regulatory elements that regulate the gene expression.
No significant difference was observed in the number of reads generated in the two cell lines for the different histone modification marks or for RNA Pol II Studentt's t-test, P-value range: 0.17-0.83).
Such histone modifications or 'marks' lead to the recruitment and subsequent docking of regulatory protein complexes that modulate transcription.
