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All in all, these data indicated that the phenotypes in these Clock knockout mESCs should mainly be due to the loss of Clock but not the influence of off-target gene modifications or loss of other Clock functions.
The goal of the study was to identify any normal genes that may become inactivated in malignant cells, with associated modifications or loss of gene products.
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We study how changes in the animal community cascade to affect forest structure, composition and services through the modification or loss of ecological processes.
However, the previous methods could not guarantee the security against modification or loss of the key seeds considering the integrity of transmitting max 255 number of key seeds.
This observation indicates that, although resistance development can occur through various mechanisms (deletion or mutation of receptor sites, host DNases,.), modification or loss of the EPS receptor must be the most straightforward.
This is consistent with partial modification or loss of the sulfenic acid oxygen.
This indicates that the modification or loss of the Rfa2 NT has no observable effect on Rad53 activation and suggests that checkpoint establishment after DNA stress is unaffected.
Rearrangements may also be exacerbated by extensive modification or loss of the IR, which may have occurred in Sciaphila (figs. 2 and 3).
We suggest that ancestral HyPRPs with long proline-rich domains produced the current diversity through ongoing gene duplications accompanied by shortening, modification or loss of the proline-rich domains.
Two of these, rrnl-trnW (derived gene boundary F) and trnM-rrnS (boundary H) are synapomorphic for the clade ((Coloceras + Campanulotes) + (Quadraceps + Philopterus)) and are present in all members of that clade without secondary modification or loss.
They argued that this asymmetry arises because many mutational routes to receptor modification or loss can achieve resistance, while phage infectivity requires the evolution of specific binding to the modified version of the existing receptor or to an entirely different receptor, which is likely to be subject to greater mutational constraint.
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