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Normally, this reversible process of conformational change is induced and regulated by post-translational modifications or interactions with other proteins.
This priming can be any change in the post-translational modifications or interactions of the exiting components.
We thus have to assume that certain posttranslational modifications or interactions with some auxiliary/associated proteins might regulate the function of these ion channels in a dramatic manner.
It is plausible that in the brain a non-amyloidogenic αS could be converted into amyloidogenic seeds through additional modifications or interactions with lipids or protein chaperones.
Thus modifications or interactions with further partners could function as a dynamic relay, which affects conformation or flexibility of the binding interface.
Myristoylation is thought to provide the initial but weak interaction with the plasma membrane; stabilization of this membrane localization may be further strengthened through other modifications or interactions with resident plasma membrane-localized components [ 49].
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It remains to be determined whether alternative proteins substitute for Hdac6 in differentiated cells to recruit Tip60-p400 to different promoters, or if alternative mechanisms of recruitment (e.g., binding to histone modifications or interaction with sequence-specific DNA-binding proteins) are more important upon differentiation.
In addition, in contrast with the data of Tuo et al. [19], we also did not find evidence for effect modification or interaction between CFH Y402H or any of the other two major AMD risk factors: smoking or the LOC387715 A69SNPNP.
Additive relative rate model specifications were also evaluated using conditional logistic regression [ 42], which permitted testing for effect measure modification, or interaction, in an additive model context.
The central analysis examines whether this treatment effect is different in adolescents compared to adults (effect modification or interaction by age).
Examination of emergent properties or effect modification or interaction between settings or subject characteristics that differ at the level of geographic sites become possible with aggregation of related structured data across the global settings contained within the 10 ICEMR sites.
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