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Despite their potentialities, these negatively charged and hydrophilic molecules request chemical modifications or a carrier that allows cell recognition, cell internalization and moreover subcellular penetration.
However, besides the lack of posttranslational modifications or a suitable environment for membrane proteins, E. coli-mediated expression is often associated with protein misfolding or aggregation [1], imposing restrictions on large-size or oligomeric proteins.
As such, it is possible to target post-translational modifications or a specific conformation of the antigen [ 4].
However, the transcriptional activity of a gene is determined by the cumulative influences of multiple histone modifications (or a histone "code").
Perhaps by using a more extensive panel of modifications or a genome-wide screen, other candidate molecular markers for the ALT phenotype could be uncovered in future experiments.
If the toxicities recurred after the described 5-FU and oxaliplatin dose modifications, or a dose was delayed >2 weeks due to toxicity, study therapy was discontinued.
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Potential mechanisms by which H. pylori could alter asthma presentation include immune modifications or an effect on gastro-esophageal reflux disease (GERD).
Since Mr. Lee, a high school aide, doesn't have enough equity to refinance, he now needs a loan modification or a miracle.
After that, if homeowners are still unemployed or unable to make payments, lenders and borrowers would have to consider other options, including a permanent loan modification or a short sale.
Cori and I thought about this for months, but we finally decided to let the house go and stop making payments so we could pursue a mortgage modification or a short sale.
The mass spectrum showed the characteristic homologous series of ions for a long chain carbon back bone (Δm/z = 14), but whether this compound originates from the oil modification or a paint additive is unknown.
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