Sentence examples for modifications on specific from inspiring English sources

Histone modifications are the catalytic result of a large set of enzyme families that operate covalent modifications on specific residues at the histone tails.

Modifications on specific histone residues and DNA methylation play an essential role in lineage choice and cellular reprogramming.

Having accounted for differences in nucleosome distribution, the patterns of histone modifications we observed can only be attributable to active cellular mechanisms (i.e., the action of histone modifiers) which overlay the nucleosomal architecture with modifications on specific nucleosomes located within exons or within introns.

Histone modifications on specific residues correlate with either active or repressive transcription (3, 19).

Such positive and negative regulations are largely governed by posttranslational modifications on specific amino acid residues on histones (Fig.  1).

Future studies will be required to establish the effects that O-GlcNAc modifications have on the target proteins that were identified in this study, and the functional significance of the modifications on specific insulin pathway outcomes.

Given the lack of any changes observed on H3, these findings suggest that cAMP caused both site-specific and histone-specific modifications on H4.

Further studies involving a larger randomized patient cohort, as well as analysis of the effect of this modification on specific coagulation markers such as tissue plasminogen activator and fibrin D-dimer, are planned.

Similarly, there is evidence for preferential effects of oxidative modification on specific mitochondrial proteins, including aconitase, involved in energy production [54], [55].

These enzymes catalyse covalent post-translational modifications of specific residues on histone 3 (H3) and 4 (H4) N-terminal tails (e.g. deacetylation of lysine (K) 9, demethylation of K4 and methylation of K9 and K27 of H3), inducing a compacted transcriptionally inactive chromatin structure.

The main objective during the recovery phase is for the disaster area to return to normality (Alexander 2006) through continuing implementation of the recovery plan, but with the inclusion of modifications based on specific experience gained following the event.