We now know that instead of relying solely on one particular modification, the Wnt pathway is controlled by the coordinated actions of phosphorylation, ubiquitination and other PTMs.
In particular, modifications on the outer surface of the histone octamer, the so-called lateral surface, have the potential to directly influence chromatin structure by altering histone histone or histone DNA interactions (Cosgrove, 2007; Tropberger and Schneider, 2010; Tropberger et al., 2013).
Matched molecular pairs (MMPs) are commonly used to assess the importance of chemical modifications on small molecules versus a particular property [1].
This suggests that the BCL-xL interaction is dependent on particular post-translational modification(s) of the protein and only a subpopulation of the AVEN interacts with BCL-xL.
Several posttranslational modifications on histone H3 affect this interaction, and, in particular, H3K4me3, which is enriched on the promoters of actively transcribed genes, hinders AIRE binding.
In particular, the new operating conditions cause modifications on the process design and performance of the wet flue gas desulfurization (FGD) unit.
In particular, the effect of man-made drainage modifications on hydrodynamic attenuation and consequent wetland evolution is poorly understood.
Wider high-resolution maps of DNA methylation (methylome), not focusing on one particular modification/residue, can now be obtained using next generation sequencing devices [ 51, 52], and could provide insights into disease pathogenesis and identify biomarkers or potential drug targets.
Focus on one particular object.
In particular, the recently available amendment [18] has proposed some modifications on physical layer convergence protocol (PLCP) header and control packets format.
