Sentence examples for modifications of the core from inspiring English sources

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.

Zhang, Y. & Reinberg, D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.

Product stewardship innovations are characterized by incremental changes in product components, with no substantial modifications of the core product concept.

Using both fully neutronics thermal-hydraulic coupled codes (SIMMER and COUPLE), we also re-confirm the efforts step by step toward a core geometry without the recirculation zone in particular as concerns the modifications of the core geometrical shape.

At UPM, in-depth modifications of the core simulator COBAYA, able to perform neutronics diffusion calculations at both nodal and pin-by-pin levels, have been accomplished during the 7th Framework EURATOM NURESAFE project.

Here we report a robust, high-throughput targeted, quantitative mass spectrometry (MS) method to rapidly profile modifications of the core histones of chromatin that compose the epigenetic landscape, enabling comparisons among cells with differing genetic backgrounds, genomic perturbations, and drug treatments.

Enantiospecific syntheses of these compounds were reported previously and could be adapted for the synthesis of any hit compound, should it be developed further.[ 6, 7] To probe the SAR of starting compound 1, a number of modifications to the core were planned.

Structure activity relationships were developed initially by modification of the core structure and subsequently by variation of the aromatic substituents and the phosphonate ester.

Structural and SAR information guided us in the modification of the core structure leading to new templates with improved activity and toxicity/activity window.

After 3 h at 523 K under 350 ppm H2S in H2 the formation of 1.9 Ru S bond per Ru atoms is observed without modification of the core of the metallic particles (the number of Ru neighbors is unchanged).

These results demonstrate that ozonolysis is an important tool for the removal of unsaturated uronate residues from LMWHs and heparosan without modification of the core polysaccharide structure or diminution of anticoagulant activity.