Sentence examples for modifications of the central from inspiring English sources

This approach led us to design chemical modifications of the central pyrazole, which solved the poor kinase selectivity seen as a strong liability for the initial compound 1.

To further elaborate on soldier-specific modifications of the central nervous system, the authors undertook anatomical and histological examinations of the brains and SOGs of termites.

Interestingly, a similar methoxy modification on the central phenyl ring of the Congo red analogue, X-34, 46 has rendered an amyloid ligand, MeO-X-04, 47 that allows fluorescence detection of Aβ and tau deposits in postmortem sections of AD brain with good specificity.

To be catalytically competent, the FAS must be activated by a posttranslational modification of the central acyl carrier domain (ACP) by an intrinsic phosphopantetheine transferase (PPT).

Although only modest activities were observed, these results suggested that a new series of bioactive cryptophycin analogues might be available by structural modification of the central ring system of the cryptophycins.

This analysis showed the modification of the central metabolism of C. glutamicum, the cross-regulation between malic acid and glucose as well as the aspartic acid utilization as nitrogen source.

The proposed class of designs is a modification of the Central Composite Designs, in which the axial points of the traditional central composite design are replaced by some edge points of the hypercube that circumscribes the sphere of zero center and radius a.

The structural modification of the central area of the laser spot was confirmed by means of the RBS technique.

We have hypothesized that the peripheral swelling of the cornea may induce a modification of the central curvature.

The Jullieniini were envisaged as having diverged from the lineage leading to the Pachydrobiini, Triculini and Lacunopsis during the Miocene; they were considered to be united by a modification of the central tooth and adaptations of the female reproductive system (e.g., the oviduct circle complex), and another derived character state of the Triculinae, that of large shell size [ 10].

Rationally designed modifications to the central biphenyl linkage of a known NS5A series led to selection of several compounds that were synthesized and evaluated in a HCV genotype 1b replicon.