Sentence examples for modifications of template from inspiring English sources

Thus, subtle chemical modifications of template DNA strands are recognized by replicative DNA polymerases, which results in the stalling of replication.

Although SMRT sequencing is capable of directly detecting modified nucleotides by their unique polymerase kinetics without bisulfite conversion [ 32], the introduction of an amplification step abolishes its ability to detect any epigenetic modifications of template DNA.

From these points of view, conducting or semi-conducting template is more favorable for the fabrication of metal tube, because the modification of template surface is unnecessary and the growth is hopefully radial.

The reaction mixtures and cycling conditions were the same as for the first round, with modifications of the template using the product of the first amplification.

Modifications of this template through Mannich and Friedel-Crafts reactions, coupled with nucleophilic displacement and reductive aminations led to 23 final derivatives, which were pharmacologically tested.

However, further modifications of the template provided an understanding of the effect of structural modifications on pharmacokinetic properties, ultimately affording several additional series of compounds including JNJ-10181457, a compound with an improved pharmacokinetic profile.

The latter aims at providing a sequence of updates to follow in order to propagate the modifications on templates to their instances.

This activity can either be induced by the termination of the transcription reaction by reaching the end of the template or by transcription-arresting modifications of the DNA template (i.e. psoralen-crosslink).