Dunne, J. L., Overbergh, L., Purcell, A. W. & Mathieu, C. Posttranslational modifications of proteins in type 1 diabetes: the next step in finding the cure?
Lipid hydroperoxide-mediated modifications of proteins are receiving increasing attention because of their possible involvement in various degenerative diseases.
For example, post-translational modifications of proteins, such as phosphorylation or glycosylation, are very important in determining protein function.
Redox reactions of cysteine residues lead to a range of reversible post-translational modifications of proteins, regulating their functions.
One persistent challenge in membrane protein design is accomplishing extensive modifications of proteins without impairing their functionality.
The epigenetic code is embodied by DNA methylation and by chemical modifications of proteins in the chromatin structure.
Macedo, C. S., Schwarz, R. T., Todeschini, A. R., Previato, J. O. & Mendonca-Previato, L. Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation a review.
On the other hand, the hexosamine biosynthetic pathway (HBP) converts glucose to intermediate products like UDP-N-acetylglucosamine, which is critical for post-translational modifications of proteins, such as protein glycosylation.
The obtained results suggest that IL-1 affects the expression of several genes in HepG2 cells, especially those engaged in the synthesis and modifications of proteins.
We applied ensembles of 25 DIMLP networks to several datasets of the public domain and a classification problem related to post-translational modifications of proteins.
Natural post-translational modifications of proteins are generally efficient under physiological conditions and site-specific.
