Sentence examples for modifications of nucleosomal from inspiring English sources

Besides modifications of lysine residues, repressive modifications of nucleosomal histones include the symmetric dimethylation of arginines (ω-NG, ω-N′G-dimethyl arginine), which is mediated by class-II protein arginine methyltransferases (PRMTs) such as PRMT513,14 and PRMT915,16.

Posttranslational modifications of nucleosomal histones regulate several key biological processes, including cell fate decision during development and functional outcomes in terminally differentiated cells.

Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes requires extensive changes in gene expression, which are partly mediated by post-translational modifications of nucleosomal histones.

This is accomplished though cytosine methylation of DNA and post-translational modifications of nucleosomal histone tails.

To date, histone acetylation and methylation are among the most intensively studied and best characterized modifications of nucleosomal histones.

One of the most studied post-translational modifications of nucleosomal histone lysine residues is acetylation, regulated by the opposing action of HDACs and histone acetyltransferases (HATs).

Here we focus on PRMT5, an enzyme which is expressed at high levels in OL lineage cells17,18 and in gliomas28 and characterize the functional significance of a relatively under-investigated modification of nucleosomal histones50.

The covalent modification of nucleosomal histones has emerged as a major determinant of chromatin structure and gene activity.

Modification of nucleosomal core histones is thought to be a prevalent epigenetic mechanism in eukaryotic gene regulation, most likely through modulation of chromatin structure [12].

Histone deacetylases (HDACs), which act in opposition to histone acetyltransferases (HATs), control the level of histone acetylation and serve as means for post-translational modification of nucleosomal histones that influence gene expression [17].

The post-translational modification of nucleosomal histones, including acetylation, phosphorylation, methylation, ubiquitination and sumoylation, plays a key role in the regulation of gene transcription through remodelling chromatin structure [1].