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Because mitochondria are key players of cell metabolism, we asked whether modifications of metabolic or environmental conditions could influence the capacity of mitochondria-defective cells to maintain nuclear genome stability.
Modifications of metabolic pathways are important in insecticide resistance evolution.
Novel Salmonella vaccine candidates and live carriers for heterologous antigens are attenuated strains with defined genetic modifications of metabolic or virulence functions.
However, in this technique, gene modifications of metabolic control architecture as well as enzyme expression levels are coupled and result in a mixed integer nonlinear programming problem.
Nevertheless, details of the translation of environmental changes to metabolic responses i.e. the adjustment of transcriptional and post-transcriptional modifications of metabolic enzymes still remains unclear [ 12].
These differences arose mainly from post-translational modifications of metabolic enzymes (the study of which will be the subject of a separate publication, which is in preparation), and this is possibly why they were not identified on mRNA microarrays [ 14, 15].
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These mechanisms are much more difficult to identify because of the complex nature of metabolism and the many side effects caused by genetic modification of metabolic pathways.
In metabolic engineering, modification of metabolic networks is an important biotechnology and a challenging computational task.
This work provides useful information for the modification of metabolic pathway to improve succinate production.
It is very important to understand quantitatively the control exerted on the flux for the rational modification of metabolic fluxes.
To our knowledge, this is the first description of the changes and modification of metabolic interactions in the Pirenella–Heterophyes model.
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