Sentence examples for modifications of known from inspiring English sources
This involved reverse engineering, figuring out how to fold an object by exploring completed objects, and/or exploratory modifications of known origami objects (see Fig. 5d).
However, with the identification of three nontrivial modifications of known chemotypes having mGluR5 PAM activity (EC50 > 2.5 μM), scaffold hopping appears to be possible using this method.
Superoxide anion and hydrogen peroxide production as well as activity of released myeloperoxidase were determined photometrically using modifications of known methods validated in our institute for this purpose (for further details see Krumholz et al. 1995, 1993; Mühling et al. 2007, 2006, 2005, 2004, 2002).
But they are modifications of known, natural antigens.
The paper indicates methods of discovering new structures or modifications of known structures and their synthesis as well as new therapeutic strategies using prodrugs, which are expected to be successful and to broaden the knowledge on what is happening to the drug in the body, in addition to providing a molecular explanation of xenobiotics activity.
Rational design of pharmacological agents (including NO-donors) takes account of specific modifications of known molecules with the purpose of optimizing their properties mainly in terms of efficacy and safety.
Such approaches [13] may involve "retargeting" via modification of known compounds, or simply "repurposing" known compounds to new applications when target profiles are suitable.
Such enzymes may be discovered by screening microorganisms sampled from diverse environments or developed by modification of known enzymes using modern methods of protein engineering or molecular evolution.
Novel heterocyclic ring-substituted pyrimidines have been designed as inhibitors of glycogen synthase kinase-3β (GSK-3β) from the modification of known inhibitors.
This new series of compounds was structurally planned by modification of known thrombin inhibitors based on the use of acylhydrazone subunit, as a nonpeptide scaffold, and variations at P1 moiety.
To this aim, one established chemical route is the modification of known inorganic materials, in most cases oxides, via substitution or insertion of cations different from the original makeup.
